Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

关于天津市地方禁毒立法的探索

二十世纪八十年代后,毒品在中国又开始死灰复燃。针对日益严重的毒品违法犯罪,国家制定了一系列法律法规,在禁毒斗争中发挥了巨大作用。但是,由于毒品问题的特殊性和我国国情,仅全国统一禁毒立法还不够,尚需地方立法的细化和补充。本文根据对天津毒品问题的分析和对其他省、市、自治区已有地方禁毒立法的研究比较,指出了制定天津地方禁毒立法的必要性,提出了天津禁毒条例的体系设想,力求为天津的禁毒立法提供某些启示和借鉴,推动我市地方禁毒立法进程。     

确定毒品种类需检测的毒品簇

确定嫌疑人是否吸毒及吸食毒品的种类是打击毒品违法犯罪必不可少的程序。毒品检验是打击毒品犯罪的一个有力工具。可用于毒品检验的方法很多,检测的物质也不尽相同。本文着重介绍用酶联放大免疫分析法所能检测的毒品簇及具体检测物质。     

运输毒品罪主观要件研究

当前,关于运输毒品罪的认定,有许多问题存在争议,特别是主观要件方面,如关于明知的认定,是否包括间接故意,主观动机和目的是不是必备要件,共同犯罪故意的认定,对象认识错误的认定和处罚等。因而有必要对其进行分析研究,以期对铁路公安部门打击运输毒品犯罪有点滴之借鉴。     

我国学校毒品预防教育存在问题及其对策

目前,我国学校毒品预防教育仍存在着"形式主义"明显、教育方式不当、教育内容脱离实际、教育实效性不高、高校毒品预防教育薄弱等问题。为此,需采取以下对策:提高认识,加强领导;多种形式建设师资;加大政府投入,多渠道募集资金;编撰统一教材;保证课堂教学时间;完善责任机制和考核机制;将学校毒品预防教育与心理健康教育、生活技能教育、同伴教育、其他学科教学、网络技术、教育科研、家庭教育、社会教育等形式结合,拓宽学校毒品预防教育途径。     

Narco-Terrorism: The Merger of the War on Drugs and the War on Terror

The aim of this article is to analyse the phenomena of narco-terrorism and the practical measures utilised to counter this threat. By adopting the model of the crime-terror continuum developed by Tamara Makarenko, the article will outline the similarities and dissimilarities of narcotics trafficking and terrorism in order to provide a more nuanced perspective on the concept of narco-terrorism. By doing so, the article will evaluate the kind of approach taken in combating the threat of narco-terrorism.     

我国毒品泛滥的新动向

近50年来，毒品蔓延的范围已扩展到全世界五大洲200多个国家和地区，成为全球性的问题。联合国麻醉品管制署提供的资料显示，上世纪50年代，全球的吸毒人数约为910万，而目前已是2亿多人。我国毒品泛滥情况依然严重，毒品犯罪案件仍居高不下，毒品犯罪趋于国际化、网络化、隐蔽化，吸毒人员呈几何级数式增长，毒品消费市场的不断滋生扩大。本文详尽综述了近几年我国毒品泛滥的一些新情况和趋势。     

易制毒化学品犯罪及其惩治对策

目前 ,我国易制毒化学品种类较多 ,管理难度大 ,管理漏洞多 ,易制毒化学品犯罪日趋严重。易制毒化学品犯罪的主要特点是涉及数量大 ,品种多 ,主体复杂 ,隐蔽性强。严厉惩治易制毒化学品犯罪 ,必须提高认识 ,加强领导 ,堵住漏洞 ,严格对缉毒人员的培训 ,提高查缉能力 ,同时要完善相关的法律、法规。     

论加强海关缉毒国际合作

全球性的毒品泛滥愈演愈烈,对人类的生存和社会的发展构成了严重的威胁。尽管各国海关国际缉毒执法合作已取得了很大的成绩,但其中也存在不少问题。面对世界性的毒品危机,必须采取全球性禁毒战略,加强各国政府,尤其是加强海关之间的禁缉毒合作。     

Toxicology and Circumstances of Completed Suicide by Means Other than Overdose*

Abstract: To determine the prevalence and circumstances of psychoactive substances amongst nonoverdose completed suicide, 1436 consecutive cases autopsied at the NSW Department of Forensic Medicine over the period 1/1/1997–12/31/2006 were analyzed. Substances were detected in 67.2% of cases, and illicit drugs in 20.1%. Alcohol was present in 40.6% of cases. Males were more likely to be positive for alcohol, cannabis, and psychostimulants, and females for pharmaceuticals. Illicits were associated with younger age. Alcohol was most prominent amongst toxicity cases, as were opioids, psychostimulants amongst gunshot cases, and pharmaceuticals amongst drownings. Cases in which drug and alcohol histories were noted were more likely to have a substance detected. Alcohol was more common where a suicide note was left and where relationship problems were involved. Pharmaceuticals were more common where a previous attempt was noted. Licit and illicit substances are strongly associated with suicide, even when the method does not involve drug overdose.